Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
2001-6-20
pubmed:abstractText
Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1 (CKLF1). The full-length cDNA of CKLF1 is 530 bp long and a single open reading frame encoding 99 amino acid residues. CKLF1 bears no significant similarity to any other known cytokine in its amino acid sequence. Expression of CKLF1 can be partly inhibited by interleukin 10 in PHA-stimulated U937 cells. Recombinant CKLF1 is a potent chemoattractant for neutrophils, monocytes and lymphocytes; moreover, it can stimulate the proliferation of murine skeletal muscle cells. These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-10065704, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-10200250, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-10354549, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-10559234, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-1311831, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-1939050, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-1940799, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-2674553, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-6353126, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-8041633, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-8597956, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-8650213, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-8702936, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-8996246, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9051728, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9104803, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9312138, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9520602, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9548457, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9691168, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9861016, http://linkedlifedata.com/resource/pubmed/commentcorrection/11415443-9920759
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
357
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-35
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
pubmed-meshheading:11415443-Humans, pubmed-meshheading:11415443-Animals, pubmed-meshheading:11415443-Mice, pubmed-meshheading:11415443-Lymphocytes, pubmed-meshheading:11415443-Monocytes, pubmed-meshheading:11415443-Muscle, Skeletal, pubmed-meshheading:11415443-Electric Stimulation, pubmed-meshheading:11415443-Cell Division, pubmed-meshheading:11415443-Base Sequence, pubmed-meshheading:11415443-RNA, Messenger, pubmed-meshheading:11415443-Amino Acid Sequence, pubmed-meshheading:11415443-Neutrophils, pubmed-meshheading:11415443-Organ Specificity, pubmed-meshheading:11415443-Cell Line, pubmed-meshheading:11415443-Chemotaxis, pubmed-meshheading:11415443-Mice, Inbred BALB C, pubmed-meshheading:11415443-Molecular Sequence Data, pubmed-meshheading:11415443-Transcription, Genetic, pubmed-meshheading:11415443-Cercopithecus aethiops, pubmed-meshheading:11415443-Base Pairing, pubmed-meshheading:11415443-Cloning, Molecular, pubmed-meshheading:11415443-Sequence Alignment, pubmed-meshheading:11415443-Sequence Homology, Amino Acid, pubmed-meshheading:11415443-Chemotaxis, Leukocyte, pubmed-meshheading:11415443-DNA, Complementary, pubmed-meshheading:11415443-Transfection, pubmed-meshheading:11415443-Recombinant Proteins
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