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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2001-6-19
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pubmed:abstractText |
Identification of factors regulating myocardial structure and function is important to understand the pathogenesis of heart disease. Because little is known about the molecular mechanism of cardiac functions triggered by serotonin, the link between downstream signaling circuitry of its receptors and the heart physiology is of widespread interest. None of the serotonin receptor (5-HT(1A), 5-HT(1B), or 5-HT(2C)) disruptions in mice have resulted in cardiovascular defects. In this study, we examined 5-HT(2B) receptor-mutant mice to assess the putative role of serotonin in heart structure and function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AndriantsitohainaRR,
pubmed-author:DouchetM PMP,
pubmed-author:GyörgyKK,
pubmed-author:HickelPP,
pubmed-author:LaunayJ MJM,
pubmed-author:ManivetPP,
pubmed-author:MaroteauxLL,
pubmed-author:MessaddeqNN,
pubmed-author:MonassierLL,
pubmed-author:NebigilC GCG,
pubmed-author:PECKH MHM,
pubmed-author:VoneschJ LJL
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
103
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2973-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11413089-Adrenergic beta-Agonists,
pubmed-meshheading:11413089-Animals,
pubmed-meshheading:11413089-Animals, Newborn,
pubmed-meshheading:11413089-Biological Markers,
pubmed-meshheading:11413089-Body Weight,
pubmed-meshheading:11413089-Cadherins,
pubmed-meshheading:11413089-Cardiomyopathies,
pubmed-meshheading:11413089-Cell Count,
pubmed-meshheading:11413089-Cell Separation,
pubmed-meshheading:11413089-Cell Size,
pubmed-meshheading:11413089-Cytoskeleton,
pubmed-meshheading:11413089-Dose-Response Relationship, Drug,
pubmed-meshheading:11413089-Echocardiography,
pubmed-meshheading:11413089-Electrocardiography,
pubmed-meshheading:11413089-Female,
pubmed-meshheading:11413089-Gene Expression,
pubmed-meshheading:11413089-Heart Defects, Congenital,
pubmed-meshheading:11413089-Heart Rate,
pubmed-meshheading:11413089-Heart Ventricles,
pubmed-meshheading:11413089-Hemodynamics,
pubmed-meshheading:11413089-Male,
pubmed-meshheading:11413089-Mice,
pubmed-meshheading:11413089-Mice, Knockout,
pubmed-meshheading:11413089-Myocardium,
pubmed-meshheading:11413089-Organ Size,
pubmed-meshheading:11413089-Phenotype,
pubmed-meshheading:11413089-Receptor, Serotonin, 5-HT2B,
pubmed-meshheading:11413089-Receptors, Serotonin,
pubmed-meshheading:11413089-Sex Factors
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pubmed:year |
2001
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|
pubmed:articleTitle |
Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.
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pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, Illkirch.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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