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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-6-18
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pubmed:abstractText |
In a prospective study, clotting parameters of 37 children and adolescents with insulin-dependent diabetes mellitus (type 1 diabetes) were compared with those of a healthy control group. In a longitudinal follow-up over two years we found no statistical difference for most of the coagulation parameters investigated, including single factor analysis and coagulation inhibitors. The duration of type 1 diabetes was of no influence on these parameters. The only difference we found between patients and healthy controls was an elevation of PAI-1 in diabetics: median for PAI-1: 2.12 IU/ml in diabetics (range 0.50-8.40 IU/ml) and 0.84 IU/ml in normal controls (range 0.50-1.78 IU/ml). This difference was of statistic significance (p < 0.002) and also found in newly diagnosed patients. During observation time, none of our patients developed thrombosis or signs of vascular disease. In conclusion, we could not confirm the development of a hyper-coagulable state in pediatric diabetics, as it is described for adults with type 1 diabetes mellitus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0947-7349
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-50
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11409296-Adolescent,
pubmed-meshheading:11409296-Antithrombin III,
pubmed-meshheading:11409296-Blood Coagulation,
pubmed-meshheading:11409296-Child,
pubmed-meshheading:11409296-Child, Preschool,
pubmed-meshheading:11409296-Diabetes Mellitus, Type 1,
pubmed-meshheading:11409296-Fibrinogen,
pubmed-meshheading:11409296-Humans,
pubmed-meshheading:11409296-Infant,
pubmed-meshheading:11409296-Partial Thromboplastin Time,
pubmed-meshheading:11409296-Peptide Fragments,
pubmed-meshheading:11409296-Peptide Hydrolases,
pubmed-meshheading:11409296-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:11409296-Prospective Studies,
pubmed-meshheading:11409296-Protein C,
pubmed-meshheading:11409296-Protein S,
pubmed-meshheading:11409296-Prothrombin,
pubmed-meshheading:11409296-Prothrombin Time
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pubmed:year |
2001
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pubmed:articleTitle |
Prospective study on plasma clotting parameters in diabetic children--no evidence for specific changes in coagulation system.
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pubmed:affiliation |
Department of Pediatrics, University of Würzburg, Würzburg, Germany.
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pubmed:publicationType |
Journal Article
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