| pubmed-article:11408938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0027708 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0293442 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C1417509 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11408938 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11408938 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11408938 | pubmed:dateCreated | 2001-6-15 | lld:pubmed |
| pubmed-article:11408938 | pubmed:abstractText | Nephroblastomas (Wilms' tumors) are curable with survival rates above 80%. Some tumors, however, fail to respond to therapy and those patients have a poor prognosis. In a search for molecular markers of drug resistance, we investigated the expression of lung resistance protein (LRP) in tissue samples from 32 children with nephroblastoma by means of immunohistochemistry. LRP is a human major vault protein (MVP) and is associated with multidrug resistance of tumors. LRP/MVP expression was found in the blastemal and epithelial compartments but to a significantly lesser extent in the stromal compartment of Wilms' tumors. Expression was generally heterogeneous with respect to staining intensity and percentage of positive cells. We found significant relationships between LRP/MVP expression and chemotherapeutic pre-treatment of tumors and tumor stage. The immunohistochemical results were validated with a real-time RT-PCR technique and a significant association between protein and mRNA expression was observed. | lld:pubmed |
| pubmed-article:11408938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11408938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11408938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11408938 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11408938 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:MertensRR | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:JakseGG | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:RingertR HRH | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:ThelenPP | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:EfferthTT | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:GefellerOO | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:GranzerFF | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:BodaM IMI | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:BeniersA JAJ | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:FuzesiLL | lld:pubmed |
| pubmed-article:11408938 | pubmed:author | pubmed-author:SchultenH GHG | lld:pubmed |
| pubmed-article:11408938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11408938 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11408938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11408938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11408938 | pubmed:pagination | 163-8 | lld:pubmed |
| pubmed-article:11408938 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:meshHeading | pubmed-meshheading:11408938... | lld:pubmed |
| pubmed-article:11408938 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11408938 | pubmed:articleTitle | Differential expression of the lung resistance-related protein/major vault protein in the histological compartments of nephroblastomas. | lld:pubmed |
| pubmed-article:11408938 | pubmed:affiliation | Virtual Campus Rhineland-Palatinate, D-55033 Mainz, Germany. efferth@vcrp.de | lld:pubmed |
| pubmed-article:11408938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11408938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
