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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-6-15
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pubmed:abstractText |
Nephroblastomas (Wilms' tumors) are curable with survival rates above 80%. Some tumors, however, fail to respond to therapy and those patients have a poor prognosis. In a search for molecular markers of drug resistance, we investigated the expression of lung resistance protein (LRP) in tissue samples from 32 children with nephroblastoma by means of immunohistochemistry. LRP is a human major vault protein (MVP) and is associated with multidrug resistance of tumors. LRP/MVP expression was found in the blastemal and epithelial compartments but to a significantly lesser extent in the stromal compartment of Wilms' tumors. Expression was generally heterogeneous with respect to staining intensity and percentage of positive cells. We found significant relationships between LRP/MVP expression and chemotherapeutic pre-treatment of tumors and tumor stage. The immunohistochemical results were validated with a real-time RT-PCR technique and a significant association between protein and mRNA expression was observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vault Ribonucleoprotein Particles,
http://linkedlifedata.com/resource/pubmed/chemical/Vincristine,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin,
http://linkedlifedata.com/resource/pubmed/chemical/major vault protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1019-6439
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pubmed:author |
pubmed-author:BeniersA JAJ,
pubmed-author:BodaM IMI,
pubmed-author:EfferthTT,
pubmed-author:FuzesiLL,
pubmed-author:GefellerOO,
pubmed-author:GranzerFF,
pubmed-author:JakseGG,
pubmed-author:MertensRR,
pubmed-author:RingertR HRH,
pubmed-author:SchultenH GHG,
pubmed-author:ThelenPP
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11408938-Antibiotics, Antineoplastic,
pubmed-meshheading:11408938-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11408938-Child,
pubmed-meshheading:11408938-Child, Preschool,
pubmed-meshheading:11408938-DNA Primers,
pubmed-meshheading:11408938-Dactinomycin,
pubmed-meshheading:11408938-Drug Resistance, Multiple,
pubmed-meshheading:11408938-Humans,
pubmed-meshheading:11408938-Immunoenzyme Techniques,
pubmed-meshheading:11408938-Kidney Neoplasms,
pubmed-meshheading:11408938-Neoplasm Proteins,
pubmed-meshheading:11408938-RNA, Messenger,
pubmed-meshheading:11408938-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11408938-Tumor Markers, Biological,
pubmed-meshheading:11408938-Vault Ribonucleoprotein Particles,
pubmed-meshheading:11408938-Vincristine,
pubmed-meshheading:11408938-Wilms Tumor,
pubmed-meshheading:11408938-beta 2-Microglobulin
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pubmed:year |
2001
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pubmed:articleTitle |
Differential expression of the lung resistance-related protein/major vault protein in the histological compartments of nephroblastomas.
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pubmed:affiliation |
Virtual Campus Rhineland-Palatinate, D-55033 Mainz, Germany. efferth@vcrp.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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