To determine the cytotoxicity of valproic acid (VPA) and its metabolite, 4-ene-valproic acid (4-ene-VPA) in human hepatoblastoma cells (Hep G2), and to study the modulatory effect of cytochrome P450 2E1 induction in this model.
Division of Clinical Pharmacology, Sunnybrook & Women's College Health Sciences Centre and Department of Pathology, Toronto Health Network, Canada. manuela@sten.sunnybrook.utoronto.ca