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pubmed-article:11407809pubmed:abstractTextChrysanthemol (1), a trans-eudesmane type sesquiterpene from Chrysanthemum indicum L., possesses certain anti-inflammatory activity. Its total synthesis was approached from two alternative routes and finally accomplished in ten steps from R-(+)-carvone via alpha-eudesmol (10) as the key intermediate. The overall yield is 2.4% and the spectral data of the synthetic target compound were identical with that of natural chrysanthemol (1). Seven intermediary compounds were tested for inhibitory effects on the carragenan-induced swelling of mouse paw but demonstrated no obvious activities.lld:pubmed
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pubmed-article:11407809pubmed:authorpubmed-author:LinZ YZYlld:pubmed
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pubmed-article:11407809pubmed:dateRevised2009-7-21lld:pubmed
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pubmed-article:11407809pubmed:year2001lld:pubmed
pubmed-article:11407809pubmed:articleTitleStereoselective total synthesis of chrysanthemol.lld:pubmed
pubmed-article:11407809pubmed:affiliationInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.lld:pubmed
pubmed-article:11407809pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11407809pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed