rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2001-6-15
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pubmed:abstractText |
Chrysanthemol (1), a trans-eudesmane type sesquiterpene from Chrysanthemum indicum L., possesses certain anti-inflammatory activity. Its total synthesis was approached from two alternative routes and finally accomplished in ten steps from R-(+)-carvone via alpha-eudesmol (10) as the key intermediate. The overall yield is 2.4% and the spectral data of the synthetic target compound were identical with that of natural chrysanthemol (1). Seven intermediary compounds were tested for inhibitory effects on the carragenan-induced swelling of mouse paw but demonstrated no obvious activities.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1028-6020
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
103-16
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pubmed:dateRevised |
2009-7-21
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pubmed:meshHeading |
pubmed-meshheading:11407809-Animals,
pubmed-meshheading:11407809-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11407809-China,
pubmed-meshheading:11407809-Chrysanthemum cinerariifolium,
pubmed-meshheading:11407809-Drugs, Chinese Herbal,
pubmed-meshheading:11407809-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11407809-Mice,
pubmed-meshheading:11407809-Molecular Conformation,
pubmed-meshheading:11407809-Monoterpenes,
pubmed-meshheading:11407809-Phytotherapy,
pubmed-meshheading:11407809-Plant Stems,
pubmed-meshheading:11407809-Plants, Medicinal,
pubmed-meshheading:11407809-Sesquiterpenes, Eudesmane,
pubmed-meshheading:11407809-Terpenes
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pubmed:year |
2001
|
pubmed:articleTitle |
Stereoselective total synthesis of chrysanthemol.
|
pubmed:affiliation |
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|