Linked Life Data

11407575

Source:http://linkedlifedata.com/resource/pubmed/id/11407575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-6-15
pubmed:abstractText
A novel, environmentally friendly, fluorinated solvent--ethoxynonafluorobutane--has been used to replace n-hexane in normal-phase HPLC applications. Fast gradients of methanol in ethoxynonafluorobutane on a cyano column have been successfully applied to the separation of steroids, benzodiazepines, NSAIDs, tricyclic antidepressants, beta-adrenergic blocking agents and mixtures of purines and pyrimidines. Small amounts of triethylamine and trifluoroacetic acid added to such gradients significantly improved peak shape and column performance for basic and acidic solutes. Ethoxynonafluorobutane and its mixtures with methanol have also been demonstrated to have a unique selectivity in chiral HPLC applications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
918
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
292-302
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Normal-phase high-performance liquid chromatographic separations using ethoxynonafluorobutane as hexane alternative. I. Analytical and chiral applications.
pubmed:affiliation
Discovery Analytical Chemistry, Chemical Sciences, Wyeth-Ayerst Research, Princeton, NJ 08543, USA. kaganm@war.wyeth.com
pubmed:publicationType
Journal Article