| pubmed-article:11406418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0599044 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:11406418 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:11406418 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11406418 | pubmed:dateCreated | 2001-6-14 | lld:pubmed |
| pubmed-article:11406418 | pubmed:abstractText | To study how gamma-ray-induced germ-cell mutations are fixed at the early embryonic stage of the next generation, genomic alterations in the b locus mutants (colorless melanophores) detected during development in the medaka specific-locus test (SLT) were analyzed. First, nine anonymous DNA markers linked to the b locus were cloned and mapped into the region extending about 47cM surrounding the b locus. Next, losses of paternal alleles of these DNA markers were examined in each of the 51 gamma-ray-induced b locus mutants obtained after irradiation of sperm or spermatids. In these mutants, 47 were dominant lethals, three were semi-viable and one was viable. All the mutants examined had large deletions surrounding the b locus. One viable mutant had an interstitial deletion, while all the semi-viable and dominant lethal ones appeared to have terminal deletions. Deletions extending about 20-35cM were the most frequently observed in 18 of the 51 mutants examined. The largest one extended more than 40cM. These results suggest that most of the gamma-ray induced germ cell mutations recovered as total specific-locus mutants were accompanied by large genomic deletions, which eventually led the mutant embryos to dominant lethality. | lld:pubmed |
| pubmed-article:11406418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11406418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11406418 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11406418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11406418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11406418 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11406418 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:11406418 | pubmed:author | pubmed-author:ShimadaAA | lld:pubmed |
| pubmed-article:11406418 | pubmed:author | pubmed-author:NaruseKK | lld:pubmed |
| pubmed-article:11406418 | pubmed:author | pubmed-author:ShimaAA | lld:pubmed |
| pubmed-article:11406418 | pubmed:author | pubmed-author:FukamachiSS | lld:pubmed |
| pubmed-article:11406418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11406418 | pubmed:volume | 458 | lld:pubmed |
| pubmed-article:11406418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11406418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11406418 | pubmed:pagination | 19-29 | lld:pubmed |
| pubmed-article:11406418 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:meshHeading | pubmed-meshheading:11406418... | lld:pubmed |
| pubmed-article:11406418 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11406418 | pubmed:articleTitle | Genomic analysis of gamma-ray-induced germ-cell mutations at the b locus recovered from the medaka specific-locus test. | lld:pubmed |
| pubmed-article:11406418 | pubmed:affiliation | Laboratory of Radiation Biology, Department of Biological Sciences, School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-0033, Tokyo, Japan. fukasho@biol.s.u-tokyo.ac.jp | lld:pubmed |
| pubmed-article:11406418 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11406418 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11406418 | lld:pubmed |
