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rdf:type |
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lifeskim:mentions |
umls-concept:C0033482,
umls-concept:C0166415,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0456387,
umls-concept:C1552644,
umls-concept:C1554184,
umls-concept:C1707689,
umls-concept:C1823153,
umls-concept:C1883254,
umls-concept:C2349976
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|
pubmed:issue |
13
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|
pubmed:dateCreated |
2001-6-14
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|
pubmed:abstractText |
Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:ArdeckyRR,
pubmed-author:BroderickC LCL,
pubmed-author:BrooksD ADA,
pubmed-author:DominianniS JSJ,
pubmed-author:EtgenG JGJ,
pubmed-author:FaulM MMM,
pubmed-author:KaranewskyD SDS,
pubmed-author:KauffmanR FRF,
pubmed-author:McCarthyJ RJR,
pubmed-author:Montrose-RafizadehCC,
pubmed-author:OldhamB ABA,
pubmed-author:PaternitiJ RJR,
pubmed-author:RitoC JCJ,
pubmed-author:ShukerA JAJ,
pubmed-author:TyhonasJJ,
pubmed-author:WarshawskyA MAM,
pubmed-author:WinneroskiL LLL
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|
pubmed:issnType |
Print
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pubmed:day |
21
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2061-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11405642-Animals,
pubmed-meshheading:11405642-Blood Glucose,
pubmed-meshheading:11405642-Cholesterol, HDL,
pubmed-meshheading:11405642-Diabetes Mellitus,
pubmed-meshheading:11405642-Diabetes Mellitus, Type 2,
pubmed-meshheading:11405642-Drug Design,
pubmed-meshheading:11405642-Hypoglycemic Agents,
pubmed-meshheading:11405642-Mice,
pubmed-meshheading:11405642-Mice, Inbred Strains,
pubmed-meshheading:11405642-Propionic Acids,
pubmed-meshheading:11405642-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11405642-Transcription Factors,
pubmed-meshheading:11405642-Triglycerides
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pubmed:year |
2001
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|
pubmed:articleTitle |
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
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pubmed:affiliation |
Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. Brooks_Dawn_A@Lilly.com
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pubmed:publicationType |
Journal Article
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