Linked Life Data

11404412

Source:http://linkedlifedata.com/resource/pubmed/id/11404412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-6-13
pubmed:abstractText
The mammalian striatum arises in the basal telencephalon and contains morphologically homogenous neurons that can be divided into two distinct compartments, patches and the matrix. During development, patch neurons are generated first to form a striatal primordium. After a large influx of later-born matrix neurons into this region, the unique mosaic arrangement of these two neuronal phenotypes is established. The massive migration of matrix neurons continues during the embryonic period, and they eventually comprise 80-85% of the mature striatum. To elucidate the cellular mechanism or mechanisms underlying this critical event in striatal histogenesis, we examined the migration characteristics of striatal subventricular zone (SVZ) cells at embryonic day 18 when neurogenesis peaks for matrix neurons. Using gel cultures, we show that netrin-1, one of the diffusible guidance cues expressed in the striatal ventricular zone (VZ), exerts a repulsive action on migrating SVZ cells. This effect is blocked in the presence of antibodies against Deleted in colorectal cancer (DCC), a putative receptor for netrin-1. The expression patterns of netrin-1 and DCC strongly suggest the involvement of this effect in the outward migration of SVZ cells into the striatal postmitotic region. Our cell tracing study using living brain slices demonstrates that striatal SVZ cells migrate toward and disperse throughout the striatum, in which they differentiate into phenotypes of striatal projection neurons. We suggest that netrin-1 expressed in the striatal VZ serves to guide the large influx of striatal matrix neurons into the striatal primordium and is thereby involved in the initial formation of fundamental striatal structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4272-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11404412-Animals, pubmed-meshheading:11404412-Antibodies, pubmed-meshheading:11404412-Cell Adhesion Molecules, pubmed-meshheading:11404412-Cell Count, pubmed-meshheading:11404412-Cell Differentiation, pubmed-meshheading:11404412-Cell Line, pubmed-meshheading:11404412-Cell Movement, pubmed-meshheading:11404412-Chemotaxis, pubmed-meshheading:11404412-Coculture Techniques, pubmed-meshheading:11404412-Corpus Striatum, pubmed-meshheading:11404412-Fluorescent Dyes, pubmed-meshheading:11404412-Humans, pubmed-meshheading:11404412-In Situ Hybridization, pubmed-meshheading:11404412-Kidney, pubmed-meshheading:11404412-Nerve Growth Factors, pubmed-meshheading:11404412-Neurons, pubmed-meshheading:11404412-Organ Specificity, pubmed-meshheading:11404412-Phenotype, pubmed-meshheading:11404412-Rats, pubmed-meshheading:11404412-Receptors, Cell Surface, pubmed-meshheading:11404412-Transfection, pubmed-meshheading:11404412-Tumor Suppressor Proteins
pubmed:year
2001
pubmed:articleTitle
A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons.
pubmed:affiliation
Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto 860-8556, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't