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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2001-6-13
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pubmed:abstractText |
Lack of efficacy in the treatment of hypertension with only one drug presents a problem in general practice and often requires switching to another type of drug, because higher dosage of currently used antihypertensives increases the frequency of side effects. Angiotensin II antagonists are well tolerated and there is no evidence of dose-related increase in side effects. This study in 574 hypertensives under therapy with ACE inhibitors, beta-blockers or calcium channel blockers was undertaken to determine whether direct switching to the Angiotensin II-antagonist candesartan cilexetil at its maximal dose of 16 mg is as effective and tolerable as starting therapy with candesartan cilexetil 8 mg followed by up-titration to 16 mg after 4 weeks.
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pubmed:language |
ger
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-0472
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
547-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11402910-Adolescent,
pubmed-meshheading:11402910-Adrenergic beta-Antagonists,
pubmed-meshheading:11402910-Adult,
pubmed-meshheading:11402910-Aged,
pubmed-meshheading:11402910-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:11402910-Antihypertensive Agents,
pubmed-meshheading:11402910-Benzimidazoles,
pubmed-meshheading:11402910-Biphenyl Compounds,
pubmed-meshheading:11402910-Calcium Channel Blockers,
pubmed-meshheading:11402910-Dose-Response Relationship, Drug,
pubmed-meshheading:11402910-Drug Administration Schedule,
pubmed-meshheading:11402910-Female,
pubmed-meshheading:11402910-Humans,
pubmed-meshheading:11402910-Hypertension,
pubmed-meshheading:11402910-Male,
pubmed-meshheading:11402910-Middle Aged,
pubmed-meshheading:11402910-Prospective Studies,
pubmed-meshheading:11402910-Tetrazoles,
pubmed-meshheading:11402910-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
[Change from ACE inhibitor, Ca-antagonist or beta-blocker to candesartan cilexetil: better efficacy and tolerance. SWITCH study (German study segment)].
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pubmed:affiliation |
Medizinische Klinik I, Clemenshospital Münster. baumgart-clemenshospital@t-online.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
English Abstract,
Randomized Controlled Trial,
Multicenter Study
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