Source:http://linkedlifedata.com/resource/pubmed/id/11402637
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-6-13
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pubmed:abstractText |
This study evaluated the effect of locally applied heat on the transdermal delivery of testosterone. Six healthy adult volunteers were tested three times while receiving a 5 mg androgen patch, the same patch with a heat-generating patch, and no patch at all over 12 hours. Statistically significant differences in mean maximum serum testosterone concentration values were seen. Heat plus patch resulted in a mean maximum serum testosterone concentration of 939 ng/dl versus 635 ng/dl (patch only) and 425 ng/dl (no patch). (Heat + patch vs. no patch: p < 0.001; heat + patch vs. patch: p < 0.001; patch vs. no patch: p = 0.003.) The area under the curve of plasma testosterone concentration versus time values were means of 4114 ng/dl.h versus 1985 ng/dl.h for the patch-only group (p = 0.001). The use of heat improved absorption of transdermal testosterone and decreased time to peak serum testosterone concentrations, resulting in a statistically significant difference in mean maximum serum testosterone concentrations compared with the use of the patch without heat.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0091-2700
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
677-82
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11402637-Administration, Cutaneous,
pubmed-meshheading:11402637-Adult,
pubmed-meshheading:11402637-Cross-Over Studies,
pubmed-meshheading:11402637-Hot Temperature,
pubmed-meshheading:11402637-Humans,
pubmed-meshheading:11402637-Male,
pubmed-meshheading:11402637-Middle Aged,
pubmed-meshheading:11402637-Pilot Projects,
pubmed-meshheading:11402637-Testosterone,
pubmed-meshheading:11402637-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
A pilot study assessing the impact of heat on the transdermal delivery of testosterone.
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pubmed:affiliation |
University of Hawaii, John A. Burns School of Medicine, 1960 East-West Road, Honolulu, HI 96822-2319, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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