rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-6-11
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pubmed:abstractText |
Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4388
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
320-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11399430-Animals,
pubmed-meshheading:11399430-Calcium,
pubmed-meshheading:11399430-Calcium Channels,
pubmed-meshheading:11399430-Calcium Signaling,
pubmed-meshheading:11399430-Calcium-Binding Proteins,
pubmed-meshheading:11399430-Exocytosis,
pubmed-meshheading:11399430-Humans,
pubmed-meshheading:11399430-Ion Transport,
pubmed-meshheading:11399430-Membrane Glycoproteins,
pubmed-meshheading:11399430-Nerve Endings,
pubmed-meshheading:11399430-Nerve Tissue Proteins,
pubmed-meshheading:11399430-Neurotransmitter Agents,
pubmed-meshheading:11399430-Receptors, Presynaptic,
pubmed-meshheading:11399430-Synaptic Transmission,
pubmed-meshheading:11399430-Synaptic Vesicles,
pubmed-meshheading:11399430-Synaptotagmins
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pubmed:year |
2001
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pubmed:articleTitle |
How does calcium trigger neurotransmitter release?
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pubmed:affiliation |
Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA. georgea@neuro.duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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