Source:http://linkedlifedata.com/resource/pubmed/id/11399290
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2001-6-11
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pubmed:abstractText |
Radiations are known to cause behavioural perturbations like conditioned taste aversion (CTA), performance decrement, learning, etc., even at very low doses. The manifestation of radiation-induced behavioural degradation has not been understood well and requires further studies. Therefore, the effects of low-dose whole-body 60Co gamma-irradiation in male rats were studied in terms of body weight and CTA learning. For CTA, the consumption of saccharin solution was considered as a parameter. To protect against the adverse effects of radiation, Centella asiatica (aqueous extract) was tested and compared with ondansetron, a standard antiemetic drug. A dose of 2 Gy incurred significant body weight loss [t(9)=9.00, P<.05] and induced CTA in rats [t(26)=9.344, P<.01]. Administration of C. asiatica (100 mg/kg bw ip, 2 Gy, -1 h) rendered significant radioprotection against radiation-induced body weight loss and CTA that became evident on the second postirradiation day [t(7)=0.917, P>>.05; t(7)=4.016, P>.05]. Ondansetron (1 mg/kg bw) elicited higher degree of protection against CTA [t(7)=3.641, P>.05] than C. asiatica [t(7)=7.196, P>.05] on the first postirradiation day, but on the second postirradiation day, both were equally effective [t(7)=3.38, P>.05; t(7)=4.01, P>.05]. In case of C. asiatica-treated animals, however, there was a consistently declining CTA from the second to the fifth postirradiation day whereas in ondansetron-treated animals it was inconsistent. Present investigation suggests that C. asiatica could be useful in preventing radiation-induced behavioural changes during clinical radiotherapy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Ondansetron,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Protective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/TECA,
http://linkedlifedata.com/resource/pubmed/chemical/Triterpenes
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0031-9384
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-23
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:11399290-Animals,
pubmed-meshheading:11399290-Avoidance Learning,
pubmed-meshheading:11399290-Cobalt Radioisotopes,
pubmed-meshheading:11399290-Conditioning, Classical,
pubmed-meshheading:11399290-Dose-Response Relationship, Radiation,
pubmed-meshheading:11399290-Male,
pubmed-meshheading:11399290-Ondansetron,
pubmed-meshheading:11399290-Radiation-Protective Agents,
pubmed-meshheading:11399290-Radioisotope Teletherapy,
pubmed-meshheading:11399290-Rats,
pubmed-meshheading:11399290-Rats, Wistar,
pubmed-meshheading:11399290-Taste,
pubmed-meshheading:11399290-Triterpenes,
pubmed-meshheading:11399290-Weight Loss,
pubmed-meshheading:11399290-Whole-Body Irradiation
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pubmed:year |
2001
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pubmed:articleTitle |
Protection against radiation-induced conditioned taste aversion by Centella asiatica.
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pubmed:affiliation |
Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences, DRDO, Lucknow Marg, New Delhi 110 054, India.
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pubmed:publicationType |
Journal Article
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