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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-6-11
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pubmed:abstractText |
Recombinant adeno-associated virus (AAV) has attracted tremendous interest as a promising vector for gene delivery. In this study we have developed an HIV-1 vaccine, using an AAV vector expressing HIV-1 env, tat, and rev genes (AAV-HIV vector). A single injection of the AAV-HIV vector induced strong production of HIV-1-specific serum IgG and fecal secretory IgA antibodies as well as MHC class I-restricted CTL activity in BALB/c mice. The titer of HIV-1-specific serum IgG remained stable for 10 months. When AAV-HIV vector was coadministered with AAV-IL2 vector, the HIV-specific cell-mediated immunity (CMI) was significantly enhanced. Boosting with AAV-HIV vector strongly enhanced the humoral response. Furthermore, the mouse antisera neutralized an HIV-1 homologous strain, and BALB/c mice immunized via the intranasal route with an AAV vector expressing the influenza virus hemagglutinin (HA) gene showed protective immunity against homologous influenza virus challenge. These results demonstrate that AAV-HIV vector immunization may provide a novel and promising HIV vaccination strategy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, rev,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinin Glycoproteins...,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1043-0342
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pubmed:author |
pubmed-author:HamajimaKK,
pubmed-author:ImaiMM,
pubmed-author:MizukamiHH,
pubmed-author:MonahanJJ,
pubmed-author:NomiyamaHH,
pubmed-author:NomiyamaKK,
pubmed-author:OkudaKK,
pubmed-author:OzawaKK,
pubmed-author:SaitoTT,
pubmed-author:TseD CDC,
pubmed-author:UrabeMM,
pubmed-author:YangJJ
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1047-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11399227-AIDS Vaccines,
pubmed-meshheading:11399227-Amino Acid Sequence,
pubmed-meshheading:11399227-Animals,
pubmed-meshheading:11399227-Cell Line,
pubmed-meshheading:11399227-Cytokines,
pubmed-meshheading:11399227-Dependovirus,
pubmed-meshheading:11399227-Disease Models, Animal,
pubmed-meshheading:11399227-Female,
pubmed-meshheading:11399227-Gene Products, rev,
pubmed-meshheading:11399227-Gene Products, tat,
pubmed-meshheading:11399227-Genes, env,
pubmed-meshheading:11399227-Genes, tat,
pubmed-meshheading:11399227-HIV Antibodies,
pubmed-meshheading:11399227-HIV-1,
pubmed-meshheading:11399227-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:11399227-Humans,
pubmed-meshheading:11399227-Immune Sera,
pubmed-meshheading:11399227-Immunoglobulin G,
pubmed-meshheading:11399227-Influenza A virus,
pubmed-meshheading:11399227-Interferon-gamma,
pubmed-meshheading:11399227-Mice,
pubmed-meshheading:11399227-Mice, Inbred BALB C,
pubmed-meshheading:11399227-Molecular Sequence Data,
pubmed-meshheading:11399227-Neutralization Tests,
pubmed-meshheading:11399227-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11399227-Vaccines, Synthetic,
pubmed-meshheading:11399227-Viral Vaccines,
pubmed-meshheading:11399227-rev Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:11399227-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2001
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pubmed:articleTitle |
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus.
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pubmed:affiliation |
Department of Bacteriology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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