| pubmed-article:11397808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:11397808 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:11397808 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:11397808 | pubmed:dateCreated | 2001-8-6 | lld:pubmed |
| pubmed-article:11397808 | pubmed:abstractText | An early step in the process of HIV-1 entry into target cells is the activation of its envelope glycoprotein (GP120-GP41) to a fusogenic state upon binding to target cell CD4 and cognate co-receptor. Incubation of human immunodeficiency virus (HIV)-1 Env-expressing cells with an excess of CD4 and co-recepeptor-bearing target cells resulted in an influx of an impermeant nucleic acid-staining fluorescent dye into the Env-expressing cells. The dye influx occurred concomitant with cell fusion. No influx of dye into target cells was observed if they were incubated with an excess of Env-expressing cells. The permeabilization of Env-expressing cells was also triggered by CD4.co-receptor complexes attached to Protein G-Sepharose beads in the absence of target cells. The CD4 and co-receptor-induced permeabilization of Env-expressing cells occurred with the same specificity with respect to co-receptor usage as cell fusion. Natural ligands for the co-receptors and C-terminal GP41 peptide inhibitors of HIV-1 fusion blocked this effect. Our results indicate that the process of HIV-1 Env-mediated fusion is initiated by the destabilization of HIV-1 Env-expressing membranes. Further elucidation of these early intermediates may help identify and develop potential inhibitors of HIV-1 entry into cells. | lld:pubmed |
| pubmed-article:11397808 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11397808 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11397808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11397808 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11397808 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11397808 | pubmed:author | pubmed-author:BlumenthalRR | lld:pubmed |
| pubmed-article:11397808 | pubmed:author | pubmed-author:XiaoXX | lld:pubmed |
| pubmed-article:11397808 | pubmed:author | pubmed-author:DimitrovD SDS | lld:pubmed |
| pubmed-article:11397808 | pubmed:author | pubmed-author:DimitrovA SAS | lld:pubmed |
| pubmed-article:11397808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11397808 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11397808 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11397808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11397808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11397808 | pubmed:pagination | 30335-41 | lld:pubmed |
| pubmed-article:11397808 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11397808 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11397808 | pubmed:articleTitle | Early intermediates in HIV-1 envelope glycoprotein-mediated fusion triggered by CD4 and co-receptor complexes. | lld:pubmed |
| pubmed-article:11397808 | pubmed:affiliation | Laboratory of Experimental and Computational Biology, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA. | lld:pubmed |
| pubmed-article:11397808 | pubmed:publicationType | Journal Article | lld:pubmed |
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