| pubmed-article:11396961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C1335654 | lld:lifeskim |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C1705326 | lld:lifeskim |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C0021699 | lld:lifeskim |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C0215508 | lld:lifeskim |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11396961 | lifeskim:mentions | umls-concept:C2362652 | lld:lifeskim |
| pubmed-article:11396961 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11396961 | pubmed:dateCreated | 2001-6-8 | lld:pubmed |
| pubmed-article:11396961 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:abstractText | The functions of AML1 in hematopoietic differentiation are repressed by AML1-mutants including the AML1/ETO chimeric protein, which is seen in t(8;21) acute myeloid leukemia. Erythroid progenitors of the patients with t(8;21) AML expressed AML1/ETO. To investigate the effect of AML1/ETO in erythroid cells, we made a tetracycline-regulated AML1/ETO overexpression system in mouse erythroleukemic (MEL) cells. Enforced AML1/ETO repressed the terminal erythroid differentiation. Furthermore, we performed representational difference analysis using this MEL cell system to clone the downstream targets of AML1 in erythroid cell differentiation. We cloned a novel transmembrane protein, Art-1 (AML1-regulated transmembrane protein 1), which is a member of tetramembrane spanning superfamily. Art-1 expression was restricted in hematopoietic cells. It was upregulated by AML1 and downregulated by AML1/ETO in both erythroid and myeloid cells, and increased during erythroid cell differentiation. Art-1 may play an important role in the differentiation of erythroid cells, possibly as a direct downstream target of AML1. | lld:pubmed |
| pubmed-article:11396961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11396961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11396961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11396961 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11396961 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11396961 | pubmed:author | pubmed-author:KimuraAA | lld:pubmed |
| pubmed-article:11396961 | pubmed:author | pubmed-author:HaradaYY | lld:pubmed |
| pubmed-article:11396961 | pubmed:author | pubmed-author:HaradaHH | lld:pubmed |
| pubmed-article:11396961 | pubmed:author | pubmed-author:DowningJ RJR | lld:pubmed |
| pubmed-article:11396961 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11396961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11396961 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11396961 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:11396961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11396961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11396961 | pubmed:pagination | 714-22 | lld:pubmed |
| pubmed-article:11396961 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11396961 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11396961 | pubmed:articleTitle | A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. | lld:pubmed |
| pubmed-article:11396961 | pubmed:affiliation | Department of Hematology/Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. | lld:pubmed |
| pubmed-article:11396961 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:27027 | entrezgene:pubmed | pubmed-article:11396961 | lld:entrezgene |
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