| pubmed-article:11396630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C0005684 | lld:lifeskim |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:11396630 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:11396630 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11396630 | pubmed:dateCreated | 2001-6-8 | lld:pubmed |
| pubmed-article:11396630 | pubmed:abstractText | Matrix metalloproteinases (MMPs) are proteolytic enzymes important at several points during multistep neoplastic progression. Although MMP-1 and MMP-3 have been implicated in the progression of various human cancers, their expression in bladder cancer has not been addressed. Immunohistochemistry (Strept-ABC-HRP method) and in situ hybridization were performed to detect MMP-1 protein, MMP-3 protein, and MMP-3 mRNA, respectively, in 59 transitional cell bladder carcinomas. To assess the role of these MMPs in bladder cancer, their expression was evaluated in relation to known clinicopathologic parameters and patients' disease-free and overall survival. Immunoreactivity for MMP-1 and MMP-3 proteins was observed in the cytoplasm of cancer cells in 30.5% and 24% of samples, respectively. Transcripts for MMP-3 mRNA were localized in stromal cells in 71.2% of cases and in cancer cells in 49% of cases. MMP-1 immunoreactivity demonstrated a statistically significant association with deeply invasive and grade III tumors versus superficial and lower grade tumors. MMP-3 protein immunoreactivity and MMP-3 mRNA immunolocalization did not associate with the parameters studied. However, MMP-3 mRNA localization in stromal cells demonstrated a borderline association with poor patients' disease-free and overall survival. In conclusion, the authors' results demonstrate a differential expression between MMP-1 and MMP-3 in bladder cancer; MMP-1 appears to participate in invasiveness and possibly in loss of differentiation in urothelial carcinomas in contrast to MMP-3. | lld:pubmed |
| pubmed-article:11396630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11396630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396630 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11396630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11396630 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11396630 | pubmed:issn | 1541-2016 | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:Constantinide... | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:DimopoulosCC | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:NakopoulouLL | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:ZervasAA | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:GiannopoulouI... | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:LiapisHH | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:LazarisA CAC | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:KyriakouGG | lld:pubmed |
| pubmed-article:11396630 | pubmed:author | pubmed-author:GakiopoulouHH | lld:pubmed |
| pubmed-article:11396630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11396630 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11396630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11396630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11396630 | pubmed:pagination | 130-7 | lld:pubmed |
| pubmed-article:11396630 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
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| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:meshHeading | pubmed-meshheading:11396630... | lld:pubmed |
| pubmed-article:11396630 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11396630 | pubmed:articleTitle | MMP-3 mRNA and MMP-3 and MMP-1 proteins in bladder cancer: a comparison with clinicopathologic features and survival. | lld:pubmed |
| pubmed-article:11396630 | pubmed:affiliation | Department of Pathology, Medical School, The National and Kapodistrian University of Athens, Greece. lnakopou@cc.uoa.gr | lld:pubmed |
| pubmed-article:11396630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11396630 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11396630 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11396630 | lld:pubmed |
