Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
2001-6-8
pubmed:abstractText
The in vivo uptake of dodecahydro-closo-dodecaborate derivatives substituted with phosphate- and bisphosphonate groups was evaluated in two different experimental tumor model systems and compared to other boronated and non-boronated compounds. These phosphorous-containing boron clusters may have potential for use in boron neutron capture therapy, a chemoradiotherapeutic form of cancer treatment. Using the F98 rat glioma as a brain tumor model in syngeneic Fischer rats, there was selective tumor uptake of the phosphate derivative with 21.5 micrograms boron/g tumor versus 5.2 micrograms/g normal brain and a tumor:blood ratio of 2.7. However, this compound was toxic to test animals and lethal at relatively low doses. The uptake of the bisphosphonate by the murine K8 osteosarcoma was approximately 18 micrograms boron/g tumor with a T:Bl ratio of 7.6 and a tumor:bone ratio of 1.5. This compound was non toxic to the test animals. The results indicate that phosphate- and bisphosphonate derivatives of dodecahydro-closo-dodecaborate may have potential for BNCT of gliomas and osteosarcomas, respectively.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11396173-Animals, pubmed-meshheading:11396173-Bone Neoplasms, pubmed-meshheading:11396173-Boron Compounds, pubmed-meshheading:11396173-Boron Neutron Capture Therapy, pubmed-meshheading:11396173-Brain Neoplasms, pubmed-meshheading:11396173-Diphosphonates, pubmed-meshheading:11396173-Glioma, pubmed-meshheading:11396173-Mice, pubmed-meshheading:11396173-Mice, Inbred BALB C, pubmed-meshheading:11396173-Molecular Structure, pubmed-meshheading:11396173-Neoplasms, Experimental, pubmed-meshheading:11396173-Osteosarcoma, pubmed-meshheading:11396173-Phosphates, pubmed-meshheading:11396173-Phosphorus Compounds, pubmed-meshheading:11396173-Rats, pubmed-meshheading:11396173-Rats, Inbred F344, pubmed-meshheading:11396173-Technetium Tc 99m Medronate, pubmed-meshheading:11396173-Tissue Distribution, pubmed-meshheading:11396173-Tumor Cells, Cultured
pubmed:articleTitle
In vivo evaluation of phosphorous-containing derivatives of dodecahydro-closo-dodecaborate for boron neutron capture therapy of gliomas and sarcomas.
pubmed:affiliation
College of Pharmacy, Ohio State University, 500 W. 12th Ave, Columbus, Ohio 43210, USA. tjarks.1@osu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Evaluation Studies