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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-7
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pubmed:abstractText |
Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated that low concentrations of Kainate receptor (KAR) agonists increased the success rate (P(s)) of uIPSCs, whereas high concentrations of KAR agonists depressed GABAergic synapses. Ambient glutamate released by basal activities or stimulation of the stratum radiatum increases the efficacy of GABAergic synapses by activating presynaptic KARs, which facilitate Ca(2+)-dependent GABA release. The results suggest that glutamate released from excitatory synapses may also function as an intermediary between excitatory and inhibitory synapses to protect overexcitation of local circuits.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f...,
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GYKI 53405,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-methyl-4-carboxyphenylglycine,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
503-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11395010-2-Amino-5-phosphonovalerate,
pubmed-meshheading:11395010-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:11395010-Animals,
pubmed-meshheading:11395010-Benzoates,
pubmed-meshheading:11395010-Benzodiazepines,
pubmed-meshheading:11395010-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:11395010-Enzyme Inhibitors,
pubmed-meshheading:11395010-Evoked Potentials,
pubmed-meshheading:11395010-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11395010-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11395010-Glycine,
pubmed-meshheading:11395010-Hippocampus,
pubmed-meshheading:11395010-Interneurons,
pubmed-meshheading:11395010-Kainic Acid,
pubmed-meshheading:11395010-Neurons,
pubmed-meshheading:11395010-Protein Kinase C,
pubmed-meshheading:11395010-Pyramidal Cells,
pubmed-meshheading:11395010-Quinoxalines,
pubmed-meshheading:11395010-Rats,
pubmed-meshheading:11395010-Rats, Sprague-Dawley,
pubmed-meshheading:11395010-Receptors, Kainic Acid,
pubmed-meshheading:11395010-Staurosporine,
pubmed-meshheading:11395010-Synapses,
pubmed-meshheading:11395010-Tetradecanoylphorbol Acetate,
pubmed-meshheading:11395010-Tetrodotoxin,
pubmed-meshheading:11395010-gamma-Aminobutyric Acid
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pubmed:year |
2001
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pubmed:articleTitle |
A kainate receptor increases the efficacy of GABAergic synapses.
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pubmed:affiliation |
Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Room 220, Valhalla, NY 10595, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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