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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-7
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pubmed:abstractText |
Islet-2 is a LIM/homeodomain-type transcription factor of the Islet-1 family expressed in embryonic zebrafish. Two Islet-2 molecules bind to the LIM domain binding protein (Ldb) dimers. Overexpression of the LIM domains of Islet-2 or the LIM-interacting domain of Ldb proteins prevented binding of Islet-2 to Ldb proteins in vitro and caused similar in vivo defects in positioning, peripheral axonal outgrowth, and neurotransmitter expression by the Islet-2-positive primary sensory and motor neurons as the defects induced by injection of Islet-2-specific antisense morpholino oligonucleotide. These and other experiments, i.e., mosaic analysis, coexpression of full-length Islet-2, and overexpression of the chimeric LIM domains derived from two different Islet-1 family members, demonstrated that Islet-2 regulates neuronal differentiation by forming a complex with Ldb dimers and possibly with some other Islet-2-specific cofactors.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LIM-Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/insulin gene enhancer binding...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-36
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11395004-Animals,
pubmed-meshheading:11395004-Axons,
pubmed-meshheading:11395004-Binding Sites,
pubmed-meshheading:11395004-Embryo, Nonmammalian,
pubmed-meshheading:11395004-Genes, Reporter,
pubmed-meshheading:11395004-Green Fluorescent Proteins,
pubmed-meshheading:11395004-Homeodomain Proteins,
pubmed-meshheading:11395004-LIM-Homeodomain Proteins,
pubmed-meshheading:11395004-Luminescent Proteins,
pubmed-meshheading:11395004-Mosaicism,
pubmed-meshheading:11395004-Motor Neurons,
pubmed-meshheading:11395004-Nerve Tissue Proteins,
pubmed-meshheading:11395004-Neurons, Afferent,
pubmed-meshheading:11395004-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:11395004-Protein Biosynthesis,
pubmed-meshheading:11395004-RNA, Messenger,
pubmed-meshheading:11395004-Transcription, Genetic,
pubmed-meshheading:11395004-Transcription Factors,
pubmed-meshheading:11395004-Zebrafish
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pubmed:year |
2001
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pubmed:articleTitle |
Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish.
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pubmed:affiliation |
Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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