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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-7
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pubmed:abstractText |
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy. We generated transgenic mice in which orexin-containing neurons are ablated by orexinergic-specific expression of a truncated Machado-Joseph disease gene product (ataxin-3) with an expanded polyglutamine stretch. These mice showed a phenotype strikingly similar to human narcolepsy, including behavioral arrests, premature entry into rapid eye movement (REM) sleep, poorly consolidated sleep patterns, and a late-onset obesity, despite eating less than nontransgenic littermates. These results provide evidence that orexin-containing neurons play important roles in regulating vigilance states and energy homeostasis. Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATXN3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mjd protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins,
http://linkedlifedata.com/resource/pubmed/chemical/polyglutamine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:BeuckmannC TCT,
pubmed-author:ChemelliR MRM,
pubmed-author:GotoKK,
pubmed-author:HaraJJ,
pubmed-author:NambuTT,
pubmed-author:SakuraiTT,
pubmed-author:SintonC MCM,
pubmed-author:SugiyamaFF,
pubmed-author:WillisJ BJB,
pubmed-author:YagamiKK,
pubmed-author:YanagisawaMM
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11394998-Animals,
pubmed-meshheading:11394998-Carrier Proteins,
pubmed-meshheading:11394998-Eating Disorders,
pubmed-meshheading:11394998-Female,
pubmed-meshheading:11394998-Humans,
pubmed-meshheading:11394998-Hypothalamus,
pubmed-meshheading:11394998-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11394998-Machado-Joseph Disease,
pubmed-meshheading:11394998-Male,
pubmed-meshheading:11394998-Mice,
pubmed-meshheading:11394998-Mice, Inbred C57BL,
pubmed-meshheading:11394998-Mice, Inbred DBA,
pubmed-meshheading:11394998-Mice, Transgenic,
pubmed-meshheading:11394998-Narcolepsy,
pubmed-meshheading:11394998-Nerve Tissue Proteins,
pubmed-meshheading:11394998-Neurons,
pubmed-meshheading:11394998-Neuropeptides,
pubmed-meshheading:11394998-Neurotransmitter Agents,
pubmed-meshheading:11394998-Nuclear Proteins,
pubmed-meshheading:11394998-Obesity,
pubmed-meshheading:11394998-Peptides,
pubmed-meshheading:11394998-Repressor Proteins,
pubmed-meshheading:11394998-Sequence Deletion,
pubmed-meshheading:11394998-Sleep, REM,
pubmed-meshheading:11394998-Sleep Stages,
pubmed-meshheading:11394998-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.
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pubmed:affiliation |
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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