Linked Life Data

11394372

Source:http://linkedlifedata.com/resource/pubmed/id/11394372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-6-6
pubmed:abstractText
Clinically, Gore-Tex Expanded-Polytetrafluoroethylene (E-PTFE) has been used to reconstruct the lateral temporomandibular joint (TMJ) ligament. The purpose of this study was to assess changes in the biomechanical properties of implanted E-PTFE over time with respect to tissue infiltration. Ninety-six specimens of implants were divided into four groups. Group A was the experimental group. Thirty-six autoclave-sterilized specimens were subcutaneously implanted into the backs of 36 rats. The rats were randomly sacrificed at 2 (n = 12), 7 (n = 12) and 12 (n = 12) weeks. The implants were tested for mechanical properties including maximal stress, strain and Young's modulus of elasticity (E) using the servo-hydraulic material testing system (MTS). Group B was the in vitro control group. Thirty-six specimens were placed in tissue culture media at 37 degrees C for a time period equivalent to the experimental group to simulate the effect of a moist, warm environment on biomechanical properties. Group C was the temperature and pressure control group. Twelve specimens were autoclave-sterilized to determine the changes of tensile strength under high temperature and pressure. Control group D (no treatment) was tested to determine the initial tensile strength. The results showed significantly larger maximal stress as well as an increase in E and smaller maximal strain in experimental group A than in control groups B, C and D. There was no significant difference among control groups B, C and D. Histological examination of implants at 12 weeks demonstrated that 0.2-0.3 mm of 1-mm thick implants were occupied by connective tissue from each side. It may be concluded that E-PTFE implants become stronger and less flexible after implantation in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0305-182X
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Evaluation of biomechanical properties of Expanded-Polytetrafluoroethylene Soft Tissue Patch after dorsal implantation in the rat to mimic TMJ lateral reconstruction.
pubmed:affiliation
Research Center for Biomedical Materials, Taipei Medical College, Taiwan. laitw@tmc.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies