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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5514
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pubmed:dateCreated |
2001-4-9
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pubmed:abstractText |
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:AltmanJ DJD,
pubmed-author:AmaraR RRR,
pubmed-author:CandidoM AMA,
pubmed-author:EarlP LPL,
pubmed-author:GrimmB DBD,
pubmed-author:HerndonJ GJG,
pubmed-author:HulseyM LML,
pubmed-author:KozyrN LNL,
pubmed-author:LydyS LSL,
pubmed-author:MaH LHL,
pubmed-author:McClureH MHM,
pubmed-author:McNichollJ MJM,
pubmed-author:MillerJJ,
pubmed-author:MontefioriD CDC,
pubmed-author:MossBB,
pubmed-author:O'NeilS PSP,
pubmed-author:RobinsonH LHL,
pubmed-author:SmithJ MJM,
pubmed-author:StapransS ISI,
pubmed-author:VillingerFF,
pubmed-author:WyattL SLS,
pubmed-author:XuYY
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
292
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-74
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11393868-AIDS Vaccines,
pubmed-meshheading:11393868-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:11393868-Animals,
pubmed-meshheading:11393868-Antibodies, Viral,
pubmed-meshheading:11393868-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11393868-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11393868-Germinal Center,
pubmed-meshheading:11393868-HIV Antibodies,
pubmed-meshheading:11393868-HIV-1,
pubmed-meshheading:11393868-Immunity, Mucosal,
pubmed-meshheading:11393868-Immunization, Secondary,
pubmed-meshheading:11393868-Immunologic Memory,
pubmed-meshheading:11393868-Interferon-gamma,
pubmed-meshheading:11393868-Lymph Nodes,
pubmed-meshheading:11393868-Macaca mulatta,
pubmed-meshheading:11393868-SAIDS Vaccines,
pubmed-meshheading:11393868-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:11393868-Simian immunodeficiency virus,
pubmed-meshheading:11393868-T-Lymphocytes,
pubmed-meshheading:11393868-Vaccines, DNA,
pubmed-meshheading:11393868-Vaccines, Synthetic,
pubmed-meshheading:11393868-Vaccinia virus,
pubmed-meshheading:11393868-Viral Load
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pubmed:year |
2001
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pubmed:articleTitle |
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
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pubmed:affiliation |
Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30329, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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