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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22-23
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pubmed:dateCreated |
2001-6-5
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pubmed:abstractText |
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2467-72
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pubmed:dateRevised |
2010-8-10
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pubmed:meshHeading |
pubmed-meshheading:11392614-Animals,
pubmed-meshheading:11392614-Carbachol,
pubmed-meshheading:11392614-Cholinergic Agonists,
pubmed-meshheading:11392614-Circadian Rhythm,
pubmed-meshheading:11392614-Cyclic GMP,
pubmed-meshheading:11392614-Models, Biological,
pubmed-meshheading:11392614-Muscarinic Antagonists,
pubmed-meshheading:11392614-Neurons,
pubmed-meshheading:11392614-Rats,
pubmed-meshheading:11392614-Receptor, Muscarinic M1,
pubmed-meshheading:11392614-Receptors, Muscarinic,
pubmed-meshheading:11392614-Signal Transduction,
pubmed-meshheading:11392614-Suprachiasmatic Nucleus
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pubmed:year |
2001
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pubmed:articleTitle |
Role of the M1 receptor in regulating circadian rhythms.
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pubmed:affiliation |
Department of Cell & Structural Biology, University of Illinois at Urbana-Champaign, 61801, USA. mgillett@uiuc.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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