rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
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pubmed:dateCreated |
2001-6-5
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pubmed:abstractText |
We describe the identification and in vitro characterization of a series of 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the 20S proteasome. Our initial SAR data demonstrate that the 2-aminobenzylstatine core structure can effectively serve as the basis for designing potent, selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chymotrypsin,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Library,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/statine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1317-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11392545-Amino Acids,
pubmed-meshheading:11392545-Anti-Inflammatory Agents,
pubmed-meshheading:11392545-Antineoplastic Agents,
pubmed-meshheading:11392545-Chymotrypsin,
pubmed-meshheading:11392545-Cysteine Endopeptidases,
pubmed-meshheading:11392545-Enzyme Inhibitors,
pubmed-meshheading:11392545-Humans,
pubmed-meshheading:11392545-Inhibitory Concentration 50,
pubmed-meshheading:11392545-Multienzyme Complexes,
pubmed-meshheading:11392545-Oligopeptides,
pubmed-meshheading:11392545-Peptide Library,
pubmed-meshheading:11392545-Proteasome Endopeptidase Complex,
pubmed-meshheading:11392545-Protein Binding,
pubmed-meshheading:11392545-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
A new structural class of selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.
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pubmed:affiliation |
Oncology Research, Novartis Pharma Inc, Basel, Switzerland. carlos.garcia-echeverria@pharma.novartis.com
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pubmed:publicationType |
Journal Article
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