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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-6-5
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pubmed:abstractText |
A new diaryl-methylene piperidine derivative, 2, displayed an atypical antipsychotic profile both in vitro and in vivo. The main pharmacological characteristics of this compound appears to reside in a more potent antagonism of the 5-HT2 serotonergic receptor than of the D2 dopaminergic receptor. This confirms that molecules displaying a D2/5-HT2 binding ratio < 1 possess clozapine-like antipsychotic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1313-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:11392544-Animals,
pubmed-meshheading:11392544-Antipsychotic Agents,
pubmed-meshheading:11392544-Disease Models, Animal,
pubmed-meshheading:11392544-Dose-Response Relationship, Drug,
pubmed-meshheading:11392544-Drug Evaluation, Preclinical,
pubmed-meshheading:11392544-Mice,
pubmed-meshheading:11392544-Piperidines,
pubmed-meshheading:11392544-Protein Binding,
pubmed-meshheading:11392544-Psychomotor Agitation,
pubmed-meshheading:11392544-Psychotic Disorders,
pubmed-meshheading:11392544-Receptors, Dopamine D2,
pubmed-meshheading:11392544-Receptors, Serotonin,
pubmed-meshheading:11392544-Serotonin Antagonists
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pubmed:year |
2001
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pubmed:articleTitle |
Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?
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pubmed:affiliation |
UCB SA, Pharma Sector, Chemin du Foriest, Braine-l'Alleud, Belgium. patrice.talaga@ucb-group.com
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pubmed:publicationType |
Journal Article
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