Source:http://linkedlifedata.com/resource/pubmed/id/11391742
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0885-3185
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2001 Movement Disorder Society.
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11391742-Adult,
pubmed-meshheading:11391742-Aged,
pubmed-meshheading:11391742-Case-Control Studies,
pubmed-meshheading:11391742-Circadian Rhythm,
pubmed-meshheading:11391742-Disease Progression,
pubmed-meshheading:11391742-Female,
pubmed-meshheading:11391742-Follow-Up Studies,
pubmed-meshheading:11391742-Humans,
pubmed-meshheading:11391742-Huntington Disease,
pubmed-meshheading:11391742-Hypokinesia,
pubmed-meshheading:11391742-Male,
pubmed-meshheading:11391742-Middle Aged,
pubmed-meshheading:11391742-Monitoring, Ambulatory,
pubmed-meshheading:11391742-Motor Activity,
pubmed-meshheading:11391742-Predictive Value of Tests
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pubmed:year |
2001
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pubmed:articleTitle |
Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.
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pubmed:affiliation |
Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. j.p.p.van_vugt@lumc.nl
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pubmed:publicationType |
Journal Article
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