Source:http://linkedlifedata.com/resource/pubmed/id/11391541
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
HLA alleles are known to be associated with susceptibility to develop autoimmune hepatitis (AH), and hepatitis A virus (HAV) infection is postulated as a putative trigger for AH. We investigated whether HLA may influence the outcome of the HAV infection by studying 67 children with self-limited and 39 children with protracted forms of this infection. HLA typing of the uncomplicated forms showed no significant increase of any HLA class I or II alleles. In contrast, DRB1*1301 was present in 46.1% of the children with protracted forms (vs. 9.8% in healthy controls; relative risk [RR]: 7.6; chi(2) = 33.3; P = 2 x 10(-9)). In uncomplicated hepatitis, 45% developed anti-smooth muscle antibody (SMA)/actin antibodies, but only 1 child had detectable antibodies after 3 months of infection onset. In contrast, after 1 year, 69% of the patients suffering protracted forms had titers of anti-SMA/actin antibodies that ranged between 1:40 and 1:160. Within their follow-up, 2 patients developed a Hashimoto's thyroiditis, but the remaining patients showed no signs of developing autoimmune hepatitis. We conclude that the DRB1*1301 haplotype is strongly associated with the protracted forms of HAV infection and suggest that the infection allows a sustained release of liver self-antigens. However, other still-unknown susceptibility genes are required for the full development of pediatric AH.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1512-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11391541-Acute Disease,
pubmed-meshheading:11391541-Adolescent,
pubmed-meshheading:11391541-Biological Markers,
pubmed-meshheading:11391541-Child,
pubmed-meshheading:11391541-Child, Preschool,
pubmed-meshheading:11391541-Chronic Disease,
pubmed-meshheading:11391541-Female,
pubmed-meshheading:11391541-HLA-DR Antigens,
pubmed-meshheading:11391541-HLA-DRB1 Chains,
pubmed-meshheading:11391541-Haplotypes,
pubmed-meshheading:11391541-Hepatitis, Autoimmune,
pubmed-meshheading:11391541-Hepatitis A,
pubmed-meshheading:11391541-Humans
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pubmed:year |
2001
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pubmed:articleTitle |
Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB*1301, a marker for pediatric autoimmune hepatitis.
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pubmed:affiliation |
División Inmunogenogenética, Hospital de Clínicas, and Departmento de Microbiología e Immunología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. inmuno@fmed.uba.ar
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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