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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-6-6
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pubmed:abstractText |
Enhanced hepatocellular trafficking of cholesterol to the bile canaliculus and cholesterol hypersecretion appears critical for gallstone formation. Therefore, we studied in more detail the hepatic cholesterol transport pathways in a mouse model of cholesterol gallstone disease. Biliary lipid secretion rates, plasma lipoprotein levels, hepatic expression of lipoprotein receptors, lipid regulatory enzymes, and putative cholesterol transporting proteins were analyzed in gallstone-susceptible C57L/J and gallstone-resistant AKR/J mice, which were fed a lithogenic diet. Biliary cholesterol hypersecretion in C57L mice was associated with decreased plasma high-density lipoprotein (HDL) cholesterol levels and significant hepatic induction of the HDL receptor (SRBI) and cholesteryl ester hydrolase. In response to the lithogenic diet, fatty-acid binding protein of liver (FABPL) was markedly induced in both mouse strains. Caveolin 1 was elevated only in plasma membranes of gallstone-susceptible C57L mice, which also failed to down-regulate cholesterol synthesis. These data suggest a role of the reverse cholesterol transport pathway for genetically determined gallstone susceptibility in the mouse.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/high density lipoprotein binding...,
http://linkedlifedata.com/resource/pubmed/chemical/high density lipoprotein receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-9139
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1451-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11391534-Animals,
pubmed-meshheading:11391534-Bile,
pubmed-meshheading:11391534-Carrier Proteins,
pubmed-meshheading:11391534-Cholelithiasis,
pubmed-meshheading:11391534-Cholesterol,
pubmed-meshheading:11391534-Diet,
pubmed-meshheading:11391534-Enzymes,
pubmed-meshheading:11391534-Gene Expression,
pubmed-meshheading:11391534-Genetic Predisposition to Disease,
pubmed-meshheading:11391534-Immunity, Innate,
pubmed-meshheading:11391534-Lipid Metabolism,
pubmed-meshheading:11391534-Lipoproteins,
pubmed-meshheading:11391534-Lipoproteins, HDL,
pubmed-meshheading:11391534-Liver,
pubmed-meshheading:11391534-Mice,
pubmed-meshheading:11391534-Mice, Inbred AKR,
pubmed-meshheading:11391534-Mice, Inbred Strains,
pubmed-meshheading:11391534-RNA-Binding Proteins,
pubmed-meshheading:11391534-Receptors, LDL,
pubmed-meshheading:11391534-Receptors, Lipoprotein,
pubmed-meshheading:11391534-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI.
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pubmed:affiliation |
Division of Gastroenterology, Department of Medicine I and the Department of Medicine II, University Hospital of Lübeck, Lübeck, Germany. fuchs@medinf.mu-luebeck.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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