Recombinant tumor necrosis factor-beta potentiated the inhibitory effect of cisplatin on intramuscularly transplanted GA-1 tumor and liver metastasis in mice. The antitumor effect was related to cytotoxic and cytostatic activities of the test preparations rather than to initiation of apoptosis.
Research Construction-and-Technology Institute of Biologically Active Substances, Vektor State Research Center, Novosibirsk, Siberia, Russia. nb@online.sinor.ru