Source:http://linkedlifedata.com/resource/pubmed/id/11390495
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2001-6-6
|
| pubmed:abstractText |
Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
166
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7427-36
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11390495-Adolescent,
pubmed-meshheading:11390495-Adult,
pubmed-meshheading:11390495-Animals,
pubmed-meshheading:11390495-Child,
pubmed-meshheading:11390495-Cytokines,
pubmed-meshheading:11390495-Elephantiasis, Filarial,
pubmed-meshheading:11390495-Female,
pubmed-meshheading:11390495-Humans,
pubmed-meshheading:11390495-Immune Tolerance,
pubmed-meshheading:11390495-Interleukin-4,
pubmed-meshheading:11390495-Ionomycin,
pubmed-meshheading:11390495-Lymphocyte Activation,
pubmed-meshheading:11390495-Male,
pubmed-meshheading:11390495-Middle Aged,
pubmed-meshheading:11390495-Papua New Guinea,
pubmed-meshheading:11390495-Phytohemagglutinins,
pubmed-meshheading:11390495-Severity of Illness Index,
pubmed-meshheading:11390495-T-Lymphocytes,
pubmed-meshheading:11390495-Tetradecanoylphorbol Acetate,
pubmed-meshheading:11390495-Th2 Cells,
pubmed-meshheading:11390495-Wuchereria bancrofti
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.
|
| pubmed:affiliation |
Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. cxk21@po.cwru.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|