| pubmed-article:11389840 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0753723 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C1511758 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11389840 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11389840 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11389840 | pubmed:dateCreated | 2001-6-6 | lld:pubmed |
| pubmed-article:11389840 | pubmed:abstractText | The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome. Siah-1, the human homolog of Drosophila seven in absentia, is a p53-inducible mediator of cell cycle arrest, tumor suppression, and apoptosis. We have now found that Siah-1 interacts with the carboxyl terminus of APC and promotes degradation of beta-catenin in mammalian cells. The ability of Siah-1 to downregulate beta-catenin signaling was also demonstrated by hypodorsalization of Xenopus embryos. Unexpectedly, degradation of beta-catenin by Siah-1 was independent of GSK3beta-mediated phosphorylation and did not require the F box protein beta-TrCP. These results indicate that APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control. | lld:pubmed |
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| pubmed-article:11389840 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11389840 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11389840 | pubmed:month | May | lld:pubmed |
| pubmed-article:11389840 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:LiuJJ | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:StevensJJ | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:ORRS HSH | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:WhiteR LRL | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:MatsunamiNN | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:NeufeldK LKL | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:YostH JHJ | lld:pubmed |
| pubmed-article:11389840 | pubmed:author | pubmed-author:RoteC ACA | lld:pubmed |
| pubmed-article:11389840 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11389840 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:11389840 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11389840 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11389840 | pubmed:pagination | 927-36 | lld:pubmed |
| pubmed-article:11389840 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11389840 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11389840 | pubmed:articleTitle | Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. | lld:pubmed |
| pubmed-article:11389840 | pubmed:affiliation | Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. | lld:pubmed |
| pubmed-article:11389840 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11389840 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11389840 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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