Source:http://linkedlifedata.com/resource/umls/id/C0753723
MSH: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.,NCI: APC protein is expressed in many tissues. The cytoplasmic APC complex may regulate cell adhesion or transmission of contact inhibition signals into cells. APC is associated with beta-Catenin, which binds and activates E-Cadherin that controls formation and maintenance of epithelial adherens junctions. The APC/ASEF/beta-Catenin complex regulates the actin cytoskeleton and cell morphology/migration. Inactivating mutations of APC cause accumulation of beta-Catenin, which binds TCF4 and increases transcription of target genes (e.g., c-MYC) and binds GSK3-beta in the WNT signaling pathway. APC is a nucleocytoplasmic shuttle protein. During mitosis, APC localizes to microtubule ends within kinetochores forming a complex with BUB1 and BUB3 checkpoint proteins. APC mutant cells form mitotic spindles with microtubules that ineffectively connect with kinetochores, leading to chromosomal instabili