| pubmed-article:11389021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C0684336 | lld:lifeskim |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C0042520 | lld:lifeskim |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:11389021 | lifeskim:mentions | umls-concept:C1136143 | lld:lifeskim |
| pubmed-article:11389021 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11389021 | pubmed:dateCreated | 2001-6-4 | lld:pubmed |
| pubmed-article:11389021 | pubmed:abstractText | Leukocyte capture and rolling are mediated by selectins expressed on leukocytes (L-selectin) and the vascular endothelium (P- and E-selectin). To investigate the role of core 2 beta1-6-N-glucosaminyltransferase (C2GlcNAcT-I) for synthesis of functional selectin ligands in vivo, leukocyte rolling flux and velocity were studied in venules of untreated and tumor necrosis factor-alpha (TNFalpha)-pretreated autoperfused cremaster muscles of C2GlcNAcT-I-deficient (core 2(-/-)) and littermate control mice. In untreated core 2(-/-) mice, leukocyte rolling was dramatically reduced with markedly increased rolling velocities (81 +/- 4 microm/s vs 44 +/- 3 microm/s). The reduced rolling in core 2(-/-) mice was due mainly to severely impaired binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1). Some rolling remained after blocking PSGL-1 in controls but not in core 2(-/-) mice. In TNFalpha-pretreated mice, rolling was markedly reduced in core 2(-/-) mice owing to impaired P-selectin- and E-selectin-mediated rolling. Rolling velocities in core 2(-/-) mice treated with an E-selectin-blocking monoclonal antibody (59 +/- 4 microm/s) were significantly higher than in controls (14 +/- 1 microm/s), which provides further evidence for the severe impairment in P-selectin-mediated rolling. In conclusion, P-selectin ligands including PSGL-1 are largely C2GlcNAcT-I dependent. In addition, E-selectin-mediated rolling in vivo is partially dependent on the targeted C2GlcNAcT-I. (Blood. 2001;97:3812-3819) | lld:pubmed |
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| pubmed-article:11389021 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11389021 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11389021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11389021 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11389021 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:RaevuoriMM | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:ElliesL GLG | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:LeyKK | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:SperandioMM | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:FoyDD | lld:pubmed |
| pubmed-article:11389021 | pubmed:author | pubmed-author:ThatteAA | lld:pubmed |
| pubmed-article:11389021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11389021 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11389021 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11389021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11389021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11389021 | pubmed:pagination | 3812-9 | lld:pubmed |
| pubmed-article:11389021 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11389021 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11389021 | pubmed:articleTitle | Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. | lld:pubmed |
| pubmed-article:11389021 | pubmed:affiliation | Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:11389021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11389021 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11389021 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14537 | entrezgene:pubmed | pubmed-article:11389021 | lld:entrezgene |
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