11386982

Source:http://linkedlifedata.com/resource/pubmed/id/11386982

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005586, umls-concept:C0007292, umls-concept:C0017337, umls-concept:C0035820, umls-concept:C0170657, umls-concept:C0338831, umls-concept:C0439611, umls-concept:C2607943, umls-concept:C2926606
pubmed:issue	6
pubmed:dateCreated	2001-6-1
pubmed:abstractText	The occurrence of mania during antidepressant treatment is a key issue in the clinical management of bipolar disorder (BP). The serotonin transporter (5-HTT) is the selective site of action of most proserotonergic compounds used to treat bipolar depression. The 5-HTT gene (SLC6A4) has 2 known polymorphisms. The aim of this study was to investigate the role of the SLC6A4 variants in the pathogenesis of antidepressant-induced mania in BP.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372435
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Agents, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0003-990X
pubmed:author	pubmed-author:CatoBB, pubmed-author:KennedyJ LJL, pubmed-author:MacciardiFF, pubmed-author:MundtBB, pubmed-author:WalkerMM
pubmed:issnType	Print
pubmed:volume	58
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	539-44
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:11386982-Adult, pubmed-meshheading:11386982-Antidepressive Agents, pubmed-meshheading:11386982-Bipolar Disorder, pubmed-meshheading:11386982-Carrier Proteins, pubmed-meshheading:11386982-Community-Acquired Infections, pubmed-meshheading:11386982-Female, pubmed-meshheading:11386982-Gene Frequency, pubmed-meshheading:11386982-Genotype, pubmed-meshheading:11386982-Humans, pubmed-meshheading:11386982-Male, pubmed-meshheading:11386982-Membrane Glycoproteins, pubmed-meshheading:11386982-Membrane Transport Proteins, pubmed-meshheading:11386982-Mental Disorders, pubmed-meshheading:11386982-Nerve Tissue Proteins, pubmed-meshheading:11386982-Polymorphism, Genetic, pubmed-meshheading:11386982-Retrospective Studies, pubmed-meshheading:11386982-Serotonin, pubmed-meshheading:11386982-Serotonin Agents, pubmed-meshheading:11386982-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:11386982-Tandem Repeat Sequences
pubmed:year	2001
pubmed:articleTitle	The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings.
pubmed:affiliation	Neurogenetics Section, R-31, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario, Canada M5T 1R8. James_Kennedy@CAMH.net
pubmed:publicationType	Journal Article