| pubmed-article:11385621 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C0242632 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C0007582 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11385621 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11385621 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11385621 | pubmed:dateCreated | 2001-5-31 | lld:pubmed |
| pubmed-article:11385621 | pubmed:abstractText | Mechanisms controlling the Th1 / Th2 phenotype of a primary immune response are often discussed assuming that the generation of Th1 and Th2 cells from the common CD4(+) precursor T helper (pTh) involves an interaction of this pTh cell with an antigen-presenting cell (APC) in the form of a two-cell interaction. Other studies suggest that the outcome of this two-cell interaction is modified by the presence of other T cells. No study has analyzed primary immune responses generated in normal, non-TcR transgenic mice, following the administration of a non-infectious antigen administered without adjuvant. We show that the Th1 / Th2 phenotype of such a primary response, generated in lethally irradiated recipients reconstituted with a variety of unprimed spleen cells, depends conjointly on the amount of antigen and number of unprimed syngeneic CD4(+) T cells present, with higher amounts and numbers favoring the generation of Th2 cells. Our observations show how these quantitative variables control in an interdependent manner the Th1 / Th2 phenotype of a primary immune response, and bear upon the mechanism by which this phenotype is determined. | lld:pubmed |
| pubmed-article:11385621 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11385621 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385621 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11385621 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385621 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385621 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11385621 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11385621 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:11385621 | pubmed:author | pubmed-author:BretscherP... | lld:pubmed |
| pubmed-article:11385621 | pubmed:author | pubmed-author:IsmailNN | lld:pubmed |
| pubmed-article:11385621 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11385621 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:11385621 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11385621 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11385621 | pubmed:pagination | 1765-71 | lld:pubmed |
| pubmed-article:11385621 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
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| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:meshHeading | pubmed-meshheading:11385621... | lld:pubmed |
| pubmed-article:11385621 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11385621 | pubmed:articleTitle | More antigen-dependent CD4(+) T cell / CD4(+) T cell interactions are required for the primary generation of Th2 than of Th1 cells. | lld:pubmed |
| pubmed-article:11385621 | pubmed:affiliation | Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada. | lld:pubmed |
| pubmed-article:11385621 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11385621 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385621 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385621 | lld:pubmed |
