Source:http://linkedlifedata.com/resource/pubmed/id/11385621
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-5-31
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pubmed:abstractText |
Mechanisms controlling the Th1 / Th2 phenotype of a primary immune response are often discussed assuming that the generation of Th1 and Th2 cells from the common CD4(+) precursor T helper (pTh) involves an interaction of this pTh cell with an antigen-presenting cell (APC) in the form of a two-cell interaction. Other studies suggest that the outcome of this two-cell interaction is modified by the presence of other T cells. No study has analyzed primary immune responses generated in normal, non-TcR transgenic mice, following the administration of a non-infectious antigen administered without adjuvant. We show that the Th1 / Th2 phenotype of such a primary response, generated in lethally irradiated recipients reconstituted with a variety of unprimed spleen cells, depends conjointly on the amount of antigen and number of unprimed syngeneic CD4(+) T cells present, with higher amounts and numbers favoring the generation of Th2 cells. Our observations show how these quantitative variables control in an interdependent manner the Th1 / Th2 phenotype of a primary immune response, and bear upon the mechanism by which this phenotype is determined.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1765-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11385621-Animals,
pubmed-meshheading:11385621-Antigens,
pubmed-meshheading:11385621-CD4 Lymphocyte Count,
pubmed-meshheading:11385621-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11385621-Cells, Cultured,
pubmed-meshheading:11385621-Erythrocytes,
pubmed-meshheading:11385621-Immunophenotyping,
pubmed-meshheading:11385621-Interleukin-4,
pubmed-meshheading:11385621-Mice,
pubmed-meshheading:11385621-Mice, Inbred CBA,
pubmed-meshheading:11385621-Spleen,
pubmed-meshheading:11385621-Th1 Cells,
pubmed-meshheading:11385621-Th2 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
More antigen-dependent CD4(+) T cell / CD4(+) T cell interactions are required for the primary generation of Th2 than of Th1 cells.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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