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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-5-31
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pubmed:abstractText |
The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate that aP2 is also expressed in macrophages, has a significant role in their biological responses and contributes to the development of atherosclerosis. Apolipoprotein E (ApoE)-deficient mice also deficient for aP2 showed protection from atherosclerosis in the absence of significant differences in serum lipids or insulin sensitivity. aP2-deficient macrophages showed alterations in inflammatory cytokine production and a reduced ability to accumulate cholesterol esters when exposed to modified lipoproteins. Apoe-/- mice with Ap2+/+ adipocytes and Ap2-/- macrophages generated by bone-marrow transplantation showed a comparable reduction in atherosclerotic lesions to those with total aP2 deficiency, indicating an independent role for macrophage aP2 in atherogenesis. Through its distinct actions in adipocytes and macrophages, aP2 provides a link between features of the metabolic syndrome and could be a new therapeutic target for the prevention of atherosclerosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/FABP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:BabaevV RVR,
pubmed-author:BoordJ BJB,
pubmed-author:FazioSS,
pubmed-author:HotamisligilG SGS,
pubmed-author:LintonM FMF,
pubmed-author:MaedaKK,
pubmed-author:MakowskiLL,
pubmed-author:MorganM AMA,
pubmed-author:ParkerR ARA,
pubmed-author:SuttlesJJ,
pubmed-author:UysalK TKT
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-705
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11385507-Adipocytes,
pubmed-meshheading:11385507-Animals,
pubmed-meshheading:11385507-Aorta,
pubmed-meshheading:11385507-Apolipoproteins E,
pubmed-meshheading:11385507-Arteriosclerosis,
pubmed-meshheading:11385507-Bone Marrow Transplantation,
pubmed-meshheading:11385507-Carrier Proteins,
pubmed-meshheading:11385507-Cell Line,
pubmed-meshheading:11385507-Cholesterol Esters,
pubmed-meshheading:11385507-Diet,
pubmed-meshheading:11385507-Fatty Acid-Binding Proteins,
pubmed-meshheading:11385507-Female,
pubmed-meshheading:11385507-Foam Cells,
pubmed-meshheading:11385507-Glucose,
pubmed-meshheading:11385507-Humans,
pubmed-meshheading:11385507-Insulin,
pubmed-meshheading:11385507-Interleukin-1,
pubmed-meshheading:11385507-Interleukin-6,
pubmed-meshheading:11385507-Lipids,
pubmed-meshheading:11385507-Macrophages,
pubmed-meshheading:11385507-Male,
pubmed-meshheading:11385507-Mice,
pubmed-meshheading:11385507-Mice, Inbred C57BL,
pubmed-meshheading:11385507-Mice, Transgenic,
pubmed-meshheading:11385507-Neoplasm Proteins,
pubmed-meshheading:11385507-Nerve Tissue Proteins,
pubmed-meshheading:11385507-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11385507-Tumor Suppressor Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
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pubmed:affiliation |
Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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