Linked Life Data

11385052

Source:http://linkedlifedata.com/resource/pubmed/id/11385052

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-5-31
pubmed:abstractText
The present study was conducted to evaluate the antiatherogenic effects of dietary gamma-linolenic acid (GLA) (primrose oil) in apolipoprotein E (apoE) genetic knockout mice. Five-wk-old male mice were fed cholesterol-free diets containing 10 g/100 g lipid as corn oil (CO) [control diet, 0 mol/100 mol GLA and (n-3) polyunsaturated fatty acids (PUFA)], primrose oil (PO, 10 mol/100 mol GLA), fish oil-CO mix [FC; 9:1 wt/wt, 0 mol/100 mol GLA and 17 mol/100 mol (n-3) PUFA] or fish oil-PO mix [FP, 1:3 wt/wt, 8 mol/100 mol GLA and 5 mol/100 mol (n-3) PUFA] for 15 wk. Subsequently, diets were supplemented with cholesterol (1.25 g/100 g) and sodium cholate (0.5 g/100 g) and fed for an additional 10 and 16 wk. Plasma cholesterol and triglyceride levels generally did not differ among groups at 20, 30 and 36 wk of age. Mice fed GLA-containing diets (PO and FP) had significantly (P < 0.05) higher liver phospholipid levels of dihomo-gamma-linolenic acid, the elongated product of GLA, relative to CO and FC groups. Consumption of GLA (PO and FP diets) significantly reduced (P < 0.05) aortic vessel wall medial layer thickness at 20 and 30 wk. A parallel GLA-dependent suppression in the number of proliferating (proliferating cell nuclear antigen positive) aortic smooth muscle cells was also observed. Diets containing either GLA or (n-3) PUFA reduced (P < 0.05) atherosclerotic lesion size in 30-wk-old mice. These results indicate that dietary GLA can suppress smooth muscle cell proliferation in vivo and retard the development of diet-induced atherosclerosis in apoE knockout mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1675-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11385052-Animals, pubmed-meshheading:11385052-Aorta, Thoracic, pubmed-meshheading:11385052-Apolipoproteins E, pubmed-meshheading:11385052-Arteriosclerosis, pubmed-meshheading:11385052-Cell Division, pubmed-meshheading:11385052-Cells, Cultured, pubmed-meshheading:11385052-Cholesterol, pubmed-meshheading:11385052-Dietary Fats, Unsaturated, pubmed-meshheading:11385052-Fatty Acids, pubmed-meshheading:11385052-Fatty Acids, Essential, pubmed-meshheading:11385052-Linoleic Acids, pubmed-meshheading:11385052-Liver, pubmed-meshheading:11385052-Male, pubmed-meshheading:11385052-Mice, pubmed-meshheading:11385052-Mice, Knockout, pubmed-meshheading:11385052-Muscle, Smooth, Vascular, pubmed-meshheading:11385052-Phospholipids, pubmed-meshheading:11385052-Plant Oils, pubmed-meshheading:11385052-Triglycerides, pubmed-meshheading:11385052-gamma-Linolenic Acid
pubmed:year
2001
pubmed:articleTitle
Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice.
pubmed:affiliation
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A&M University, College Station, Texas 77840, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't