Linked Life Data

11384770

Source:http://linkedlifedata.com/resource/pubmed/id/11384770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2001-5-31
pubmed:abstractText
The use of two different polyclonal, affinity-purified, monospecific antibodies to ANG II (called BODE and BODE 1) revealed dissimilar distribution of ANG II immunoreactivity within the rat central nervous system (CNS). The ANG II-like material detected using BODE was concentrated in the neurosecretory hypothalamic nuclei, in the inner layer of the median eminence and in the posterior lobe of the pituitary. In contrast, the BODE 1 antibody did not stain the hypothalamic-neurohypophysial angiotensinergic system, and the staining pattern was much more broadly distributed throughout the CNS. BODE 1 is the first antibody that can be used to verify the locations of endogenous angiotensin and their receptor sites in the CNS. The diverse distribution of the ANG II-like material detected by the two antibodies provides strong evidence for the existence of at least two different angiotensinergic systems in the CNS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0167-0115
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-101
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
A new angiotensinergic system in the CNS of the rat.
pubmed:affiliation
University of Berne, Division of Neurobiology, Baltzerstrasse 6, CH 3012-, Bern, Switzerland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't