Source:http://linkedlifedata.com/resource/pubmed/id/11383749
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-5-31
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pubmed:abstractText |
Caspase-1 plays an important functional role mediating neuronal cell death and dysfunction after experimental traumatic brain injury (TBI) in mice. Minocycline, a derivative of the antibiotic tetracycline, inhibits caspase-1 expression. This study investigates whether minocycline can ameliorate TBI-mediated injury in mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0148-396X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1393-9; discussion 1399-401
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11383749-Animals,
pubmed-meshheading:11383749-Brain,
pubmed-meshheading:11383749-Brain Injuries,
pubmed-meshheading:11383749-Caspase 1,
pubmed-meshheading:11383749-Enzyme Activation,
pubmed-meshheading:11383749-Enzyme Inhibitors,
pubmed-meshheading:11383749-Interleukin-1,
pubmed-meshheading:11383749-Mice,
pubmed-meshheading:11383749-Mice, Inbred C57BL,
pubmed-meshheading:11383749-Minocycline,
pubmed-meshheading:11383749-Nervous System,
pubmed-meshheading:11383749-Neurons
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pubmed:year |
2001
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pubmed:articleTitle |
Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.
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pubmed:affiliation |
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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