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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0012854,
umls-concept:C0020792,
umls-concept:C0024400,
umls-concept:C0032105,
umls-concept:C0032520,
umls-concept:C0035647,
umls-concept:C0449438,
umls-concept:C0521115,
umls-concept:C0521457,
umls-concept:C0678804,
umls-concept:C1522384,
umls-concept:C1858460,
umls-concept:C1880497,
umls-concept:C1996904
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|
pubmed:issue |
5-6
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|
pubmed:dateCreated |
2001-5-31
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|
pubmed:abstractText |
Pregnancies with a Rhesus constellation still present a considerable obstetric problem. In addition, pregnancies with male Rhesus D fetuses are more severely affected by haemolytic disease of the newborn, requiring more transfusions in utero and having a three fold higher mortality than female Rhesus D fetuses. Furthermore, almost 150 X-linked genetic deficiencies have now been characterised, increasing the need for prenatal sex determination in pregnancies at risk for such a disorder. In order examine these two important fetal loci in a risk free manner, we have developed a novel multiplex real-time PCR assay for the analysis of extracellular fetal DNA in maternal plasma.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1424-7860
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
10
|
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pubmed:volume |
131
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
70-4
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pubmed:dateRevised |
2011-2-15
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pubmed:meshHeading |
pubmed-meshheading:11383228-DNA,
pubmed-meshheading:11383228-Erythroblastosis, Fetal,
pubmed-meshheading:11383228-Female,
pubmed-meshheading:11383228-Humans,
pubmed-meshheading:11383228-Infant, Newborn,
pubmed-meshheading:11383228-Male,
pubmed-meshheading:11383228-Maternal-Fetal Exchange,
pubmed-meshheading:11383228-Oncogene Proteins, Fusion,
pubmed-meshheading:11383228-Polymerase Chain Reaction,
pubmed-meshheading:11383228-Pregnancy,
pubmed-meshheading:11383228-Pregnancy Trimester, Second,
pubmed-meshheading:11383228-Prenatal Diagnosis,
pubmed-meshheading:11383228-Recombinant Fusion Proteins,
pubmed-meshheading:11383228-Rh Isoimmunization,
pubmed-meshheading:11383228-Rh-Hr Blood-Group System,
pubmed-meshheading:11383228-Risk Assessment,
pubmed-meshheading:11383228-Sex Determination Processes
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Risk free simultaneous prenatal identification of fetal Rhesus D status and sex by multiplex real-time PCR using cell free fetal DNA in maternal plasma.
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pubmed:affiliation |
Laboratory for Prenatal Medicine, Department of Obstetrics and Gynaecology, University of Basel, Switzerland.
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pubmed:publicationType |
Journal Article
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