Activation of the cysteine protease calpain has been implicated in renal ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of calpain inhibitor-1 (Cal I-1) in an in vivo model of renal I/R injury.
Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, and the Royal London School of Medicine and Dentistry, London, England, United Kingdom. p.k.chaterjee@mds.qmw.ac.uk