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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-5-30
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pubmed:abstractText |
Increased oxidative stress is considered to be a causal factor in the development of diabetic complications, among which peripheral neuropathy. The pathophysiology of nerve dysfunction in diabetes has been explained both by reduced endoneurial microcirculation and alterations in endoneurial metabolism. It is unclear whether antioxidants primarily improve nerve blood flow or normalise systemic or endoneurial oxidative metabolism. Therefore, we evaluated the effects of the antioxidants glutathione and alpha-lipoic acid on both nerve microcirculation and the antioxidative capacity and lipid peroxidation in experimentally diabetic rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11380593-Animals,
pubmed-meshheading:11380593-Antioxidants,
pubmed-meshheading:11380593-Blood Flow Velocity,
pubmed-meshheading:11380593-Diabetes Mellitus, Experimental,
pubmed-meshheading:11380593-Diabetic Neuropathies,
pubmed-meshheading:11380593-Glutathione,
pubmed-meshheading:11380593-Injections, Intraperitoneal,
pubmed-meshheading:11380593-Male,
pubmed-meshheading:11380593-Microcirculation,
pubmed-meshheading:11380593-Neural Conduction,
pubmed-meshheading:11380593-Oxidative Stress,
pubmed-meshheading:11380593-Peripheral Nerves,
pubmed-meshheading:11380593-Rats,
pubmed-meshheading:11380593-Rats, Wistar,
pubmed-meshheading:11380593-Sciatic Nerve,
pubmed-meshheading:11380593-Thioctic Acid,
pubmed-meshheading:11380593-Tibial Nerve,
pubmed-meshheading:11380593-Vascular Resistance
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pubmed:year |
2001
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pubmed:articleTitle |
Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state.
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pubmed:affiliation |
University Medical Center, Utrecht, The Netherlands. P.S.vanDam@digd.azu.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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