Linked Life Data

11380542

Source:http://linkedlifedata.com/resource/pubmed/id/11380542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-5-30
pubmed:abstractText
A selection of 17 aldehydes (13 sensitizing and 4 non-sensitizing), all of which possessed a benzene ring, were evaluated using structure-activity relationships (SARs). The sensitizing compounds were classified as strong, moderate or weak skin sensitizers on the basis of in vivo data. The aldehydes were grouped into 4 distinct subcategories of functionally related aldehydes that were termed aryl-substituted aliphatic, aryl, aryl with special features (that can undergo metabolism) and alpha,beta-unsaturated aldehydes. It was observed that a structure-activity relationship could be derived for a subset of aldehydes that could react via the same chemical mechanism. This further supports the view that applying knowledge on reaction mechanisms to develop SAR models can provide a more accurate means of investigating and predicting the sensitization potential of structurally and functionally related chemicals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0105-1873
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Skin-sensitization structure-activity relationships for aldehydes.
pubmed:affiliation
SEAC Toxicology Unit, Unilever Research Colworth, Sharnbrook, Bedford UK.
pubmed:publicationType
Journal Article