Source:http://linkedlifedata.com/resource/pubmed/id/11380474
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-5-30
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pubmed:abstractText |
Interleukin 1 (IL-1) is involved in various autoimmune and inflammatory diseases. IL-1 receptor antagonist (IL-1Ra) is the naturally occurring antagonist to IL-1alpha and -1beta. Polymorphisms of IL-1beta have been associated with variations in IL-1beta production (nucleotides +3953 and -511). A variable number tandem repeat (VNTR) polymorphism in the IL-1Ra gene has been associated (allele 2) with increased IL-1Ra production. We examined these polymorphisms in human leucocyte antigen (HLA)-matched allogeneic bone marrow transplant patients and donors. IL-1Ra VNTR (allele 2) in the donor genotype was more frequent with milder acute graft-versus-host disease (aGvHD) grades 0-II (29 out of 59 transplants) than severe GvHD grades III-IV (2 out of 18 transplants) (P = 0.0032). This association was confirmed in a subgroup with cyclosporine monotherapy prophylaxis: donor possession of allele 2 was again associated with milder aGvHD, grades 0-II (19 out of 38 transplants), than grades III-IV (1 out of 14) (P = 0.0042) transplants. No association was found between the IL-1beta -511 or IL-1beta +3953 polymorphism and severity of GvHD. Recipient IL-1Ra VNTR genotype (allele 2) showed a strong trend towards association with aGvHD severity (P = 0.0697). Thus, the donor genotype for the IL-1Ra polymorphism has an apparent protective role against acute GvHD following transplantation and may be an additional factor for individual risk assessment for complications, including GvHD, post transplant.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11380474-Adult,
pubmed-meshheading:11380474-Bone Marrow Transplantation,
pubmed-meshheading:11380474-Female,
pubmed-meshheading:11380474-Graft vs Host Disease,
pubmed-meshheading:11380474-Humans,
pubmed-meshheading:11380474-Interleukin-1,
pubmed-meshheading:11380474-Logistic Models,
pubmed-meshheading:11380474-Male,
pubmed-meshheading:11380474-Polymorphism, Genetic,
pubmed-meshheading:11380474-Receptors, Interleukin-1,
pubmed-meshheading:11380474-Retrospective Studies,
pubmed-meshheading:11380474-Risk Factors,
pubmed-meshheading:11380474-Tandem Repeat Sequences,
pubmed-meshheading:11380474-Transplantation, Homologous
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pubmed:year |
2001
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pubmed:articleTitle |
Donor interleukin 1 receptor antagonist genotype associated with acute graft-versus-host disease in human leucocyte antigen-matched sibling allogeneic transplants.
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pubmed:affiliation |
The Leukaemia Research Fund (LRF) Laboratory, Cookson Building, The Medical School, Newcastle-upon-Tyne, UK. Hannah.Cullup@ncl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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