Linked Life Data

11379273

Source:http://linkedlifedata.com/resource/pubmed/id/11379273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-5-29
pubmed:abstractText
This paper summarizes some recent findings on the physiopathology of facial pain. Over the past decade, a number of animal models of facial pain have been developed. Two of these models are discussed in more detail. The model developed by Strassman and Burstein has provided a useful tool for the study of the mechanisms underlying migraine. Single unit recordings revealed that medullary dorsal horn neurons show a long-lasting increased response to dural and cutaneous periorbital mechanical and thermal stimulation after application of inflammatory agents to the dura. In addition, dural and cutaneous receptive fields largely expanded and spontaneous ongoing activity developed. These findings suggest that the extracranial hypersensitivity that is often observed in headache may have an intracranial origin. The second model that is discussed is the model of facial neuropathic pain after infraorbital nerve ligation developed by Vos and colleagues. In contrast to the previous model which is an acute electrophysiological preparation, the infraorbital nerve model is a behavioural model. It can therefore be used both for electrophysiological and behavioural studies. In recent years, a number of functional neuroimaging studies of facial pain appeared. Studies performed in cluster headache patients seem to point to a crucial role of the hypothalamus in this syndrome. However, since hypothalamic activation has also been reported in some other types of (facial) pain, the specificity of the role of the hypothalamus in cluster headache remains to be proven.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9009
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Facial pain: from animal models to functional neuroimaging studies.
pubmed:affiliation
PET Center, Aarhus University Hospital, Aarhus, Denmark & Department of Neurology, University Hospital Saint-Etienne, France.
pubmed:publicationType
Journal Article, Review